Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Jan;4(1):108-16.
doi: 10.1513/pats.200607-141JG.

Genetics of sarcoidosis: candidate genes and genome scans

Michael C Iannuzzi  1 , Benjamin A Rybicki
Affiliations
Review

Genetics of sarcoidosis: candidate genes and genome scans

Michael C Iannuzzi et al. Proc Am Thorac Soc. 2007 Jan.

Abstract

Human leukocyte antigen class II allele associations and T-cell receptor beta chain bias in sarcoidosis suggest a specific disease-triggering antigen exposure in a genetically susceptible host. The cause of sarcoidosis has been elusive, but genetics provides one of the few promising avenues to further our understanding. We review the association studies and genome scans used to identify the genes involved in sarcoidosis.

PubMed Disclaimer

References

    1. Rybicki BA, Iannuzzi MC, Frederick MM, Thompson BW, Rossman MD, Bresnitz EA, Terrin ML, Moller DR, Barnard J, Baughman RP, et al. Familial aggregation of sarcoidosis: a case-control etiologic study of sarcoidosis (ACCESS). Am J Respir Crit Care Med 2001;164:2085–2091. - PubMed
    1. Rybicki BA, Major M, Popovich J Jr, Maliarik MJ, Iannuzzi MC. Racial differences in sarcoidosis incidence: a 5-year study in a health maintenance organization. Am J Epidemiol 1997;145:234–241. - PubMed
    1. Rybicki BA, Kirkey KL, Major M, Maliarik MJ, Popovich J Jr, Chase GA, Iannuzzi MC. Familial risk ratio of sarcoidosis in African-American sibs and parents. Am J Epidemiol 2001;153:188–193. - PubMed
    1. Harrington D, Major M, Rybicki B, Popovich J Jr, Maliarik M, Iannuzzi MC. Familial analysis of 91 families. Sarcoidosis 1994;11:240–243.
    1. Mana J, Gomez-Vaquero C, Montero A, Salazar A, Marcoval J, Valverde J, Manresa F, Pujol R. Lofgren's syndrome revisited: a study of 186 patients. Am J Med 1999;107:240–245. - PubMed

Publication types

LinkOut - more resources