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Comparative Study
. 2007 Jan;164(1):163-6.
doi: 10.1176/ajp.2007.164.1.163.

Effects of parental PTSD on the cortisol response to dexamethasone administration in their adult offspring

Rachel Yehuda  1 , William Blair, Ellen Labinsky, Linda M Bierer
Affiliations
Comparative Study

Effects of parental PTSD on the cortisol response to dexamethasone administration in their adult offspring

Rachel Yehuda et al. Am J Psychiatry. 2007 Jan.

Abstract

Objective: The authors used a low-dose dexamethasone suppression test to examine the effect of a PTSD risk factor, parental PTSD, on cortisol negative feedback inhibition in adult offspring of Holocaust survivors with PTSD (N=13) versus without PTSD (N=12) as well as a comparison group of offspring whose parents had no Holocaust exposure (N=16).

Method: Blood samples were obtained at 8:00 a.m. for the determination of baseline cortisol. Participants ingested 0.5 mg of dexamethasone at 11:00 p.m., and blood samples were obtained again at 8:00 a.m. the following day.

Results: Enhanced cortisol suppression in response to dexamethasone was associated primarily with parental PTSD status, with minimal contribution of subjects' own trauma-related symptoms.

Conclusions: Enhanced cortisol negative feedback inhibition may be associated with PTSD because it is related to the PTSD risk factor of parental PTSD.

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