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. 2007 Jan;55(1):150-2.
doi: 10.1248/cpb.55.150.

Lignans from Arctium lappa and their inhibition of LPS-induced nitric oxide production

So Young Park  1 , Seong Su Hong, Xiang Hua Han, Ji Sang Hwang, Dongho Lee, Jai Seup Ro, Bang Yeon Hwang
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Free article

Lignans from Arctium lappa and their inhibition of LPS-induced nitric oxide production

So Young Park et al. Chem Pharm Bull (Tokyo). 2007 Jan.
Free article

Abstract

A new butyrolactone sesquilignan, isolappaol C (1), together with four known lignans, lappaol C (2), lappaol D (3), lappaol F (4), and diarctigenin (5), were isolated from the methanolic extract of the seeds from the Arctium lappa plant. The structure of isolappaol C (1) was determined by spectral analysis including 1D- and 2D-NMR. All the isolates were evaluated for their inhibitory effects on the LPS-induced nitric oxide production using murine macrophage RAW264.7 cells. Lappaol F (4) and diarctigenin (5) strongly inhibited NO production in the LPS-stimulated RAW264.7 cells with IC(50) values of 9.5 and 9.6 microM, respectively.

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