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. 2006 Dec 28;12(48):7762-7.
doi: 10.3748/wjg.v12.i48.7762.

Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients

Roberto Herrera-Goepfert  1 , Jesus-K Yamamoto-Furusho, Luis-F Onate-Ocana, Margarita Camorlinga-Ponce, Leopoldo Munoz, Jorge-A Ruiz-Morales, Gilberto Vargas-Alarcon, Julio Granados
Affiliations

Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients

Roberto Herrera-Goepfert et al. World J Gastroenterol. .

Abstract

Aim: To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma.

Methods: Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosorbent assay (ELISA) method.

Results: We found a significant increased frequency of HLA-DQB1*0401 allele in H pylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P = 1 x 10(-7), odds ratio (OR) = 4.96; 95% confidence interval (95% CI), 3.87-6.35]. We also found a significant increased frequency of HLA-DQB1*0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals (P = 1 x 10(-6), OR = 13.07; 95% CI, 2.82-85.14).

Conclusion: HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and diffuse-type gastric adenocarcinoma in the Mexican Mestizo population.

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