Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Dec 1;88(23):10735-9.
doi: 10.1073/pnas.88.23.10735.

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias

S Ziemin-van der Poel  1 , N R McCabe, H J Gill, R Espinosa 3rd, Y Patel, A Harden, P Rubinelli, S D Smith, M M LeBeau, J D Rowley, et al.
Affiliations

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias

S Ziemin-van der Poel et al. Proc Natl Acad Sci U S A. .

Erratum in

  • Proc Natl Acad Sci U S A 1992 May 1;89(9):4220

Abstract

Recurring chromosomal translocations involving chromosome 11, band q23, have been observed in acute lymphoid leukemias and especially in acute myeloid leukemias. We recently showed that breakpoints in four 11q23 translocations, t(4;11)(q21;q23), t(6;11)(q27;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13.3), were contained within a yeast artificial chromosome clone bearing the CD3D and CD3G gene loci. We have identified within the CD3 yeast artificial chromosome a transcription unit that spans the breakpoint junctions of the 4;11, 9;11, and 11;19 translocations, and we describe two other, related transcripts that are upregulated in the RS4;11 cell line. We have named this gene MLL (myeloid/lymphoid, or mixed-lineage, leukemia.

PubMed Disclaimer

References

    1. Genomics. 1990 Nov;8(3):447-53 - PubMed
    1. J Natl Cancer Inst. 1983 Mar;70(3):447-53 - PubMed
    1. Genes Chromosomes Cancer. 1991 Jan;3(1):44-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1990 Dec;87(23):9358-62 - PubMed
    1. Blood. 1985 Aug;66(2):439-43 - PubMed

Publication types

MeSH terms

LinkOut - more resources