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Review
. 2007 Jan 3;27(1):1-3.
doi: 10.1523/jneurosci.4842-06.2007.

Endocannabinoid-dependent regulation of feedforward inhibition in cerebellar Purkinje cells

Cameron H Good  1
Affiliations
Review

Endocannabinoid-dependent regulation of feedforward inhibition in cerebellar Purkinje cells

Cameron H Good. J Neurosci. .
No abstract available

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Figures

Figure 1.
Figure 1.
Schematic illustration of postsynaptic eCB release from cerebellar neurons. It was previously shown that PCs could release eCBs in response to glutamatergic PF input. However, the study by Beierlein and Regehr (2006) is the first to show that cerebellar GABAergic BCs and SCs are also able to autoregulate PF inputs through retrograde eCB signaling. This action is expected to reduce the FFI of PCs, thereby increasing the inhibitory PC output to deeper cerebellar nuclei.
See this image and copyright information in PMC

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References

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    1. Beierlein M, Regehr WG. Local interneurons regulate synaptic strength by retrograde release of endocannabinoids. J Neurosci. 2006;26:9935–9943. - PMC - PubMed
    1. Eccles JC, Ito M, Szentagothai J. New York: Springer; 1967. The cerebellum as a neuronal machine.
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    1. Maejima T, Oka S, Hashimotodani Y, Ohno-Shosaku T, Aiba A, Wu D, Waku K, Sugiura T, Kano M. Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase C β4 signaling cascade in the cerebellum. J Neurosci. 2005;25:6826–6835. - PMC - PubMed

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