Time-dependent involvement of cAMP and cGMP in consolidation of object memory: studies using selective phosphodiesterase type 2, 4 and 5 inhibitors
- PMID: 17207788
- DOI: 10.1016/j.ejphar.2006.11.041
Time-dependent involvement of cAMP and cGMP in consolidation of object memory: studies using selective phosphodiesterase type 2, 4 and 5 inhibitors
Abstract
The present study investigated the time-dependent memory enhancing properties of three selective phosphodiesterase inhibitors (PDE-I) vardenafil (PDE5-I), rolipram (PDE4-I) and BAY 60-7550 (PDE2-I) in the object recognition task. In particular, the time-dependent involvement of cAMP and cGMP in memory consolidation was assessed by altering the time points of drug administration. Vardenafil (1 mg/kg, p.o.), rolipram (0.03 mg/kg, i.p.), and BAY 60-7550 (3 mg/kg, p.o.) were tested in rats with a 24 h delay between the learning and the test trial. The PDE-Is were administered at different time points, i.e. directly after, 1 h, 3 h and 6 h after the first trial. Using a 24 h interval, vardenafil only showed an effect on object memory when injected directly after trial 1, rolipram only showed an improvement when injected 3 h after trial 1 and BAY 60-7550 improved memory when injected either directly after or 3 h after trial 1. No treatment effects were found when the compounds were administered 1 h or 6 h after the first trial. Our results extend our previous data that different types of PDE-Is affect different stages of memory consolidation. Moreover, the present study provides further support that selective PDE-Is can influence memory consolidation in a time-dependent manner, assumingly by elevating central cAMP and cGMP levels.
Similar articles
-
Modulation of rat thymocyte proliferative response through the inhibition of different cyclic nucleotide phosphodiesterase isoforms by means of selective inhibitors and cGMP-elevating agents.Mol Pharmacol. 1993 Nov;44(5):1027-35. Mol Pharmacol. 1993. PMID: 8246905
-
The selective PDE5 inhibitor, sildenafil, improves object memory in Swiss mice and increases cGMP levels in hippocampal slices.Behav Brain Res. 2005 Oct 14;164(1):11-6. doi: 10.1016/j.bbr.2005.04.021. Behav Brain Res. 2005. PMID: 16076505
-
The role of phosphodiesterase isoforms 2, 5, and 9 in the regulation of NO-dependent and NO-independent cGMP production in the rat cervical spinal cord.J Chem Neuroanat. 2006 Jun;31(4):275-303. doi: 10.1016/j.jchemneu.2006.02.006. Epub 2006 Apr 18. J Chem Neuroanat. 2006. PMID: 16621445
-
Implications of PDE4 structure on inhibitor selectivity across PDE families.Int J Impot Res. 2004 Jun;16 Suppl 1:S24-7. doi: 10.1038/sj.ijir.3901211. Int J Impot Res. 2004. PMID: 15224132 Review.
-
Phosphodiesterase type 5 inhibition improves early memory consolidation of object information.Neurochem Int. 2004 Nov;45(6):915-28. doi: 10.1016/j.neuint.2004.03.022. Neurochem Int. 2004. PMID: 15312986 Review.
Cited by
-
The PDE5 inhibitor vardenafil does not affect auditory sensory gating in rats and humans.Psychopharmacology (Berl). 2013 Jan;225(2):303-12. doi: 10.1007/s00213-012-2817-7. Epub 2012 Aug 2. Psychopharmacology (Berl). 2013. PMID: 22855271 Clinical Trial.
-
Pro-cognitive effect of upregulating cyclic guanosine monophosphate signalling during memory acquisition or early consolidation is mediated by increased AMPA receptor trafficking.J Psychopharmacol. 2020 Jan;34(1):103-114. doi: 10.1177/0269881119885262. Epub 2019 Nov 6. J Psychopharmacol. 2020. PMID: 31692397 Free PMC article.
-
Increased particulate phosphodiesterase 4 in the prefrontal cortex supports 5-HT4 receptor-induced improvement of object recognition memory in the rat.Psychopharmacology (Berl). 2009 Jan;202(1-3):125-39. doi: 10.1007/s00213-008-1283-8. Epub 2008 Aug 15. Psychopharmacology (Berl). 2009. PMID: 18712363
-
Effect of acute and long term potassium bromide administration on spatial working memory in rat.Res Pharm Sci. 2017 Apr;12(2):154-159. doi: 10.4103/1735-5362.202454. Res Pharm Sci. 2017. PMID: 28515768 Free PMC article.
-
Longevity, enhanced memory, and altered density of dendritic spines in hippocampal CA3 and dentate gyrus after hemizygous deletion of Pde2a in mice.Neuropsychopharmacology. 2025 Apr;50(5):808-817. doi: 10.1038/s41386-024-02031-w. Epub 2024 Nov 27. Neuropsychopharmacology. 2025. PMID: 39604498
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical