Review
doi: 10.1016/j.mce.2006.12.009.
Epub 2007 Jan 5.
Tyrosine phosphatases in steroidogenic cells: regulation and function
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- PMID: 17207923
- DOI: 10.1016/j.mce.2006.12.009
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Review
Tyrosine phosphatases in steroidogenic cells: regulation and function
Mol Cell Endocrinol.
2007 Feb.
Abstract
In adrenocortical and Leydig cells PKA activation by trophic hormones increases the activity of protein tyrosine phosphatases and also induces the expression of MAP kinase phosphatase 1 (MKP-1), a dual activity protein phosphatase (serine/threonine and tyrosine). This work summarizes the knowledge on the regulation and the role played by cAMP-activated tyrosine phosphatases as well as MKP-1 in the hormonal activation of the acute and chronic phases of steroidogenesis.
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