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Review
. 2007 Feb:265-266:131-7.
doi: 10.1016/j.mce.2006.12.009. Epub 2007 Jan 5.

Tyrosine phosphatases in steroidogenic cells: regulation and function

Alejandra Gorostizaga  1 , Fabiana Cornejo Maciel, Laura Brion, Paula Maloberti, Ernesto J Podestá, Cristina Paz
Affiliations
Review

Tyrosine phosphatases in steroidogenic cells: regulation and function

Alejandra Gorostizaga et al. Mol Cell Endocrinol. 2007 Feb.

Abstract

In adrenocortical and Leydig cells PKA activation by trophic hormones increases the activity of protein tyrosine phosphatases and also induces the expression of MAP kinase phosphatase 1 (MKP-1), a dual activity protein phosphatase (serine/threonine and tyrosine). This work summarizes the knowledge on the regulation and the role played by cAMP-activated tyrosine phosphatases as well as MKP-1 in the hormonal activation of the acute and chronic phases of steroidogenesis.

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