Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Jan;26(1):40-9.
doi: 10.1037/0278-6133.26.1.40.

Age-associated predictors of medication adherence in HIV-positive adults: health beliefs, self-efficacy, and neurocognitive status

Terry R Barclay  1 , Charles H Hinkin, Steven A Castellon, Karen I Mason, Matthew J Reinhard, Sarah D Marion, Andrew J Levine, Ramani S Durvasula
Affiliations

Age-associated predictors of medication adherence in HIV-positive adults: health beliefs, self-efficacy, and neurocognitive status

Terry R Barclay et al. Health Psychol. 2007 Jan.

Abstract

Objective: Although most agree that poor adherence to antiretrovirals is a common problem, relatively few factors have been shown to consistently predict treatment failure. In this study, a theoretical framework encompassing demographic characteristics, health beliefs/attitudes, treatment self-efficacy, and neurocognitive status was examined in relationship to highly active antiretroviral therapy adherence.

Design: Prospective, cross-sectional observational design.

Main outcome measures: Neuropsychological test performance, health beliefs and attitudes, and medication adherence tracked over a 1-month period using electronic monitoring technology (Medication Event Monitoring System caps).

Results: The rate of poor adherence was twice as high among younger participants than with older participants (68% and 33%, respectively). Results of binary logistic regression revealed that low self-efficacy and lack of perceived treatment utility predicted poor adherence among younger individuals, whereas decreased levels of neurocognitive functioning remained the sole predictor of poor adherence among older participants.

Conclusion: These data support components of the health beliefs model in predicting medication adherence among younger HIV-positive individuals. However, risk of adherence failure in those ages 50 years and older appears most related to neurocognitive status.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Highly active antiretroviral therapy adherence as a function of age.
See this image and copyright information in PMC

References

    1. Albert SM, Weber CM, Todak G, Polanco C, Clouse R, McElhiney M. An observed performance test of medication management ability in HIV: Relation to neuropsychological status and medication adherence outcomes. AIDS Behavior. 1999;3:121–128.
    1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4. Washington, DC: Author; 1994.
    1. Ammassari A, Murri R, Pezzotti P, Trotta MP, Ravasio L, De Longis P, et al. Self-reported symptoms and medication side effects influence adherence to highly active antiretroviral therapy in persons with HIV infection. Journal of Acquired Immune Deficiency Syndrome. 2001;28:445–449. - PubMed
    1. Arnsten JH, Demas PA, Farzadegan H, Grant RW, Gourevitch MN, Change CJ, et al. Antiretroviral therapy adherence and viral suppression in HIV-infected drug users: Comparison of self-report and electronic monitoring. Clinical Infectious Diseases. 2001;33:1417–1423. - PMC - PubMed
    1. Bandura A. Self-efficacy: Toward a unifying theory of behavioral change. Psychological Review. 1977;84:191–215. - PubMed

Publication types