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. 1991 Dec;30(6):459-63.
doi: 10.1093/rheumatology/30.6.459.

Monoclonal antibody treatment in rheumatoid arthritis: the clinical and immunological effects of a CD7 monoclonal antibody

B W Kirkham  1 , C Pitzalis, G H Kingsley, I C Chikanza, S Sabharwal, C Barbatis, R Grahame, T Gibson, P L Amlot, G S Panayi
Affiliations

Monoclonal antibody treatment in rheumatoid arthritis: the clinical and immunological effects of a CD7 monoclonal antibody

B W Kirkham et al. Br J Rheumatol. 1991 Dec.

Abstract

Six patients with rheumatoid arthritis were treated with a CD7 mouse monoclonal antibody, RFT2, daily for 15 days. Only two patients had a significant improvement in clinical disease activity which lasted 7-14 days. No serious adverse effects occurred although all patients developed antibodies against mouse immunoglobulin. During treatment T-lymphocyte numbers decreased and T-lymphocyte CD7 expression was absent in all but one patient.

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