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Review
. 2007 Jan;35(1):30-4.
doi: 10.1097/JES.0b013e31802d8874.

ACTN3: A genetic influence on muscle function and athletic performance

Daniel G MacArthur  1 , Kathryn N North
Affiliations
Review

ACTN3: A genetic influence on muscle function and athletic performance

Daniel G MacArthur et al. Exerc Sport Sci Rev. 2007 Jan.

Abstract

A common variant of the ACTN3 gene, R577X, results in complete deficiency of the alpha-actinin-3 protein in the fast skeletal muscle fibers of more than a billion humans worldwide. We review the evidence that this genetic variant is strongly associated with elite athlete status and with normal variation in human muscle strength and sprinting speed.

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