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Comment
. 2007 Jan 16;104(3):689-90.
doi: 10.1073/pnas.0610679104. Epub 2007 Jan 9.

Nonpeptidic glucagon-like peptide 1 receptor agonists: a magic bullet for diabetes?

K G Murphy  1 , S R Bloom
Affiliations
Comment

Nonpeptidic glucagon-like peptide 1 receptor agonists: a magic bullet for diabetes?

K G Murphy et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of interest statement: S.R.B. is chief scientific officer, director, and shareholder of Thiakis Ltd.

Figures

Fig. 1.
Fig. 1.
GLP-1 signaling as a target for antidiabetic compounds. Exenatide and Boc5 are orthosteric agonists, and compound 2 is an allosteric agonist, of the GLP-1 receptor (GLP-1R), although the exact mechanism by which it works is unknown. Dipeptidyl peptidase-4 (DPP4) inhibitors potentiate the effects of GLP-1.
See this image and copyright information in PMC

Comment on

  • A nonpeptidic agonist of glucagon-like peptide 1 receptors with efficacy in diabetic db/db mice.
    Chen D, Liao J, Li N, Zhou C, Liu Q, Wang G, Zhang R, Zhang S, Lin L, Chen K, Xie X, Nan F, Young AA, Wang MW. Chen D, et al. Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):943-8. doi: 10.1073/pnas.0610173104. Epub 2007 Jan 9. Proc Natl Acad Sci U S A. 2007. PMID: 17213311 Free PMC article.
  • Small-molecule agonists for the glucagon-like peptide 1 receptor.
    Knudsen LB, Kiel D, Teng M, Behrens C, Bhumralkar D, Kodra JT, Holst JJ, Jeppesen CB, Johnson MD, de Jong JC, Jorgensen AS, Kercher T, Kostrowicki J, Madsen P, Olesen PH, Petersen JS, Poulsen F, Sidelmann UG, Sturis J, Truesdale L, May J, Lau J. Knudsen LB, et al. Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):937-42. doi: 10.1073/pnas.0605701104. Epub 2007 Jan 9. Proc Natl Acad Sci U S A. 2007. PMID: 17213325 Free PMC article.

References

    1. Chen D, Liao J, Li N, Zhou C, Liu Q, Wang G, Zhang R, Zhang S, Lin L, Chen K, et al. Proc Natl Acad Sci USA. 2007;104:943–948. - PMC - PubMed
    1. Knudsen LB, Kiel D, Teng M, Behrens C, Bhumralkar D, Kodra JT, Holst JJ, Jeppesen CB, Johnson MD, de Jong JC, et al. Proc Natl Acad Sci USA. 2007;104:937–942. - PMC - PubMed
    1. Larsen PJ, Holst JJ. Regul Pept. 2005;128:97–107. - PubMed
    1. Bonner-Weir S, Weir GC. Nat Biotechnol. 2005;23:857–861. - PubMed
    1. Drucker DJ, Nauck MA. Lancet. 2006;368:1696–1705. - PubMed

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