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Comment
. 2007 Jan 9;104(2):399-400.
doi: 10.1073/pnas.0610164103. Epub 2007 Jan 3.

The impact of structural biology on neurobiology

Ronald E Viola  1
Affiliations
Comment

The impact of structural biology on neurobiology

Ronald E Viola. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Metabolism of NAA in brain. NAA is produced in neurons by the condensation of activated acetate (in the form of acetyl-CoA) with l-aspartate, catalyzed by an as-yet-uncharacterized acetyltransferase. The product is transported to oligodendrocytes by a sodium/dicarboxylate cotransporter (NaC3) and then cleaved to release l-aspartate and acetate by aspartoacylase. This enzyme is defective in Canavan disease patients, leading to an accumulation of NAA and the failure to release acetate in these myelin-synthesizing cells.
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