FK 506 conversion of renal allografts failing cyclosporine immunosuppression
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- PMID: 1721365
- PMCID: PMC2967307
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FK 506 conversion of renal allografts failing cyclosporine immunosuppression
Transplant Proc.
1991 Dec.
No abstract available
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Clinical course of patient no. 27. The patient is a 30-year-old male with ESRD secondary to a connective tissue disorder with 0% panel reactive antibody undergoing primary transplantation. A severe rejection occurred 4 weeks after transplantation, which did not respond to a course of high-dose corticosteroids. The patient required dialysis on five occasions after the rejection episode began. He received two doses of OKT3 but had a severe reaction to the drug (disorientation, seizures, fluid overload) and this was discontinued. He was switched to FK 506 on day 33 following transplantation. The patient currently has a functioning graft with a SCR of 1.7 mg/dL.
Renal function in patients with functioning allografts following conversion from CyA to FK 506, excluding those patients on dialysis at the time of conversion.
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