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Comparative Study
. 2007 Apr 3;68(14):1141-3.
doi: 10.1212/01.wnl.0000254483.19854.ef. Epub 2007 Jan 10.

Evaluation of LRRK2 G2019S penetrance: relevance for genetic counseling in Parkinson disease

S Goldwurm  1 , M Zini, L Mariani, S Tesei, R Miceli, F Sironi, M Clementi, V Bonifati, G Pezzoli
Affiliations
Comparative Study

Evaluation of LRRK2 G2019S penetrance: relevance for genetic counseling in Parkinson disease

S Goldwurm et al. Neurology. .

Abstract

We report the results of a family-based study of LRRK2 G2019S penetrance in Parkinson disease. We studied 19 families identified through the analysis of unrelated consecutive patients. The cumulative incidence of the disease was 15% at 60 years, 21% at 70 years, and 32% at 80 years. This study provides accurate estimates of G2019S penetrance by minimizing the selection bias.

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