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. 2007 Jul;16(7):925-31.
doi: 10.1007/s00586-006-0301-y. Epub 2007 Jan 10.

Relation of inflammatory modic changes to intradiscal steroid injection outcome in chronic low back pain

Fouad Fayad  1 , Marie-Martine Lefevre-Colau, François Rannou, Nathaly Quintero, Alain Nys, Yann Macé, Serge Poiraudeau, Jean Luc Drapé, Michel Revel
Affiliations

Relation of inflammatory modic changes to intradiscal steroid injection outcome in chronic low back pain

Fouad Fayad et al. Eur Spine J. 2007 Jul.

Abstract

The purpose of this study was to analyze the association between the severity of inflammatory endplate changes (Modic) on MRI and the clinical response to intradiscal injection of corticosteroids (IDIC) in chronic low back pain (LBP). A total of 74 patients with LBP and inflammatory Modic changes who showed no response to 3-month conservative treatment received lumbar IDIC. Two spine specialists and a radiologist assessed independently the endplate marrow changes of the injected discs. We classified patients with a pure edema endplate changes on MRI as Modic type I (n = 37); those with a mixture of Modic type I and type II changes but predominantly edema changes as Modic I-2 (n = 25) and those with predominantly fatty changes as Modic II-1 (n = 12). The primary outcome was the change in LBP intensity between baseline and 1 month after IDIC, as measured on a visual analog scale (range 0-100 mm). At 1 month, reduction in pain score was significantly higher in the Modic I and Modic I-2 groups than in the Modic II-1 group (30.2 +/- 26.6 and 29.4 +/- 21.5 vs 5.3 +/- 25.5; P = 0.009 and P = 0.017, respectively). At 3 and 6 months, IDIC tended to be more effective in the Modic I and Modic I-2 groups but not significantly. No complications such as infection or hematoma were reported. IDIC could be a short-term efficient treatment for patients with chronic LBP and predominantly inflammatory endplate changes when conservative treatments have failed.

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Figures

Fig. 1
Fig. 1
a Modic I-2 changes of L5-S1 on MRI of the lumbar spine. MRI shows a mixture of edema and fatty changes on L5-S1, but edema changes are predominant. b Modic II-1 changes of L4-L5 on MRI of the lumbar spine. MRI shows a mixture of edema and fatty changes on L4-L5, but fatty changes are predominant
Fig. 2
Fig. 2
Mean ± SE development of low back pain intensity in the three groups. Mod I Modic I changes, Mod I-2 Modic I-2 changes, and Mod II-1, Modic II-1 changes
See this image and copyright information in PMC

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