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Case Reports
. 2007 Apr;86(4):303-6.
doi: 10.1007/s00277-006-0231-0. Epub 2007 Jan 11.

Necrobiotic xanthogranuloma successfully treated with autologous stem cell transplantation

Jeroen S Goede, Benjamin Misselwitz, Christian Taverna, Urs Schanz, Angela Dispenzieri, Yvonne Hummel, Ralph M Trüeb, Jörg Fehr
Case Reports

Necrobiotic xanthogranuloma successfully treated with autologous stem cell transplantation

Jeroen S Goede et al. Ann Hematol. 2007 Apr.

Abstract

Paraproteinemia can be complicated by necrobiotic xanthogranuloma. Therapeutic options for this progressive disease are limited, and there is no agreement on a single best strategy. We report the case of a patient with a massive periorbital infiltration narrowing the palpebral fissure and blinding the patient. Conventional myeloma therapy had only limited benefit in our patient. However, he was successfully treated with high-dose chemotherapy followed by autologous stem cell transplantation, rendering the patient free of symptoms. This is the first report of autologous stem cell transplantation in a patient with necrobiotic xanthogranuloma.

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