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Review
. 2007:313:129-44.
doi: 10.1007/978-3-540-34594-7_8.

Arsenic trioxide and acute promyelocytic leukemia: clinical and biological

Z Chen  1 , W L Zhao, Z X Shen, J M Li, S J Chen, J Zhu, V Lallemand-Breittenbach, J Zhou, M C Guillemin, D Vitoux, H de Thé
Affiliations
Review

Arsenic trioxide and acute promyelocytic leukemia: clinical and biological

Z Chen et al. Curr Top Microbiol Immunol. 2007.

Abstract

Arsenic has recently been identified as an effective drug in the treatment of newly diagnosed and relapsed acute promyelocytic leukemia. Indeed, arsenic trioxide combined with all-trans retinoic acid shows a synergistic effect. Mechanistically, arsenic targets the key leukemogenic protein PML-RARalpha, setting up a new example of molecular target-based cancer therapy.

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