doi: 10.1021/ol062599z.
Efficient synthesis of phenanthridinone derivatives via a palladium-catalyzed coupling process
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- PMID: 17217260
- DOI: 10.1021/ol062599z
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Efficient synthesis of phenanthridinone derivatives via a palladium-catalyzed coupling process
Org Lett.
.
Abstract
A palladium-mediated domino reaction was developed to conveniently synthesize phenanthridinone derivatives. Phosphine ligand 1 strongly promotes the domino process, which includes aryl-aryl coupling and C-N bond formations concomitant with a deamidation reaction. The versatility and applicability to a broad range of substrates make this reaction useful for the development of bioactive derivatives. [reaction: see text].
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