doi: 10.1021/ol062607b.
New solid support for the synthesis of 3'-oligonucleotide conjugates through glyoxylic oxime bond formation
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- PMID: 17217269
- DOI: 10.1021/ol062607b
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New solid support for the synthesis of 3'-oligonucleotide conjugates through glyoxylic oxime bond formation
Org Lett.
.
Abstract
A novel solid support 1 was synthesized to incorporate glyoxylic aldehyde functionality at the oligonucleotide 3'-terminus. 6-mer and 11-mer oligonucleotide sequences containing 3'-glyoxylic aldehyde functionality were prepared by using this support. These modified oligonucleotides were coupled to reporters containing an aminooxy group to prepare oligonucleotide 3'-conjugates through glyoxylic oxime bond formation. The hydrolytic stability of a glyoxylic oxime linkage was also investigated. [reaction: see text].
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