Review
doi: 10.1016/0952-7915(91)90020-2.
CD4-gp120 interactions
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- PMID: 1721822
- DOI: 10.1016/0952-7915(91)90020-2
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Review
CD4-gp120 interactions
Curr Opin Immunol.
1991 Aug.
Abstract
The three-dimensional structure of the binding domain of the CD4 molecule has been determined and extensive mutational analyses of the respective binding sites on gp120 and CD4 have been completed. The consequences of gp120-CD4 binding with respect to secondary changes in the virion, or the cell, that may be required for infection or that may interfere with cellular function are current active areas of investigation.
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