Review
doi: 10.1016/j.cell.2006.12.023.
PTEN enters the nuclear age
Affiliations
- PMID: 17218252
- DOI: 10.1016/j.cell.2006.12.023
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Review
PTEN enters the nuclear age
Cell.
.
Free article
Abstract
Regulation of the PTEN tumor suppressor protein is poorly understood. In this issue, Wang et al. (2007) and Trotman et al. (2007) describe how ubiquitination regulates PTEN stability and its nuclear localization. Additionally, Shen et al. (2007) report that a nuclear pool of PTEN helps to maintain chromosomal stability.
Comment on
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NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN.Cell. 2007 Jan 12;128(1):129-39. doi: 10.1016/j.cell.2006.11.039. Cell. 2007. PMID: 17218260 Free PMC article.
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Ubiquitination regulates PTEN nuclear import and tumor suppression.Cell. 2007 Jan 12;128(1):141-56. doi: 10.1016/j.cell.2006.11.040. Cell. 2007. PMID: 17218261 Free PMC article.
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Essential role for nuclear PTEN in maintaining chromosomal integrity.Cell. 2007 Jan 12;128(1):157-70. doi: 10.1016/j.cell.2006.11.042. Cell. 2007. PMID: 17218262
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