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Review
. 2007 Jan 12;25(1):1-14.
doi: 10.1016/j.molcel.2006.12.010.

Dynamic regulation of histone lysine methylation by demethylases

Yang Shi  1 , Johnathan R Whetstine
Affiliations
Free article
Review

Dynamic regulation of histone lysine methylation by demethylases

Yang Shi et al. Mol Cell. .
Free article

Abstract

Recent studies demonstrated that histone methylation is not static but is dynamically regulated by histone methyltransferases and the newly discovered histone demethylases. This review discusses the chemical mechanisms for the known and potentially new classes of demethylases, the roles of these demethylases in chromatin and transcription, and their potential biological functions and connections to human diseases.

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