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Comment
. 2007 Jan 12;315(5809):187; author reply 187.
doi: 10.1126/science.1129402.

Comment on "A common genetic variant is associated with adult and childhood obesity"

Christian Dina  1 , David Meyre, Chantal Samson, Jean Tichet, Michel Marre, Beatrice Jouret, Marie Aline Charles, Beverley Balkau, Philippe Froguel
Affiliations
Comment

Comment on "A common genetic variant is associated with adult and childhood obesity"

Christian Dina et al. Science. .

Abstract

Herbert et al. (Reports, 14 April 2006, p. 279) reported an association between the INSIG2 gene variant rs7566605 and obesity in four sample populations, under a recessive model. We attempted to replicate this result in 10,265 Caucasian individuals, combining family-based, case-control, and general population studies, but found no support for a major role of this variant in obesity.

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  • A common genetic variant is associated with adult and childhood obesity.
    Herbert A, Gerry NP, McQueen MB, Heid IM, Pfeufer A, Illig T, Wichmann HE, Meitinger T, Hunter D, Hu FB, Colditz G, Hinney A, Hebebrand J, Koberwitz K, Zhu X, Cooper R, Ardlie K, Lyon H, Hirschhorn JN, Laird NM, Lenburg ME, Lange C, Christman MF. Herbert A, et al. Science. 2006 Apr 14;312(5771):279-83. doi: 10.1126/science.1124779. Science. 2006. PMID: 16614226

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