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Comment
. 2007 Jan 12;315(5809):187; author reply 187.
doi: 10.1126/science.1130012.

Comment on "A common genetic variant is associated with adult and childhood obesity"

Ruth J F Loos  1 , Inês Barroso, Stephen O'rahilly, Nicholas J Wareham
Affiliations
Comment

Comment on "A common genetic variant is associated with adult and childhood obesity"

Ruth J F Loos et al. Science. .

Abstract

Herbert et al. (Reports, 14 April 2006, p. 279) found that the rs7566605 genetic variant, located upstream of the INSIG2 gene, was consistently associated with increased body mass index. However, we found no evidence of association between rs7566605 and body mass index in two large ethnically homogeneous population-based cohorts. On the contrary, an opposite tendency was observed.

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Comment on

  • A common genetic variant is associated with adult and childhood obesity.
    Herbert A, Gerry NP, McQueen MB, Heid IM, Pfeufer A, Illig T, Wichmann HE, Meitinger T, Hunter D, Hu FB, Colditz G, Hinney A, Hebebrand J, Koberwitz K, Zhu X, Cooper R, Ardlie K, Lyon H, Hirschhorn JN, Laird NM, Lenburg ME, Lange C, Christman MF. Herbert A, et al. Science. 2006 Apr 14;312(5771):279-83. doi: 10.1126/science.1124779. Science. 2006. PMID: 16614226

References

    1. Herbert A, et al. Science. 2006;312:279. - PubMed
    1. Day N, et al. Br. J. Cancer. 1999;80(suppl. 1):95. - PubMed
    1. Wareham NJ, Byrne CD, Williams R, Day NE, Hales CN. Diabetes Care. 1999;22:262. - PubMed

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