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Comment
. 2007 Jan 16;104(3):691-2.
doi: 10.1073/pnas.0611133104. Epub 2007 Jan 12.

Deception point: peptidoglycan modification as a means of immune evasion

Jennifer L Bishop  1 , Erin C Boyle, B Brett Finlay
Affiliations
Comment

Deception point: peptidoglycan modification as a means of immune evasion

Jennifer L Bishop et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Model of host detection and destruction of Listeria in the absence of PG N-deacetylation. (A) Listeria pgdA mutants are degraded by lysozyme in the intestinal lumen. PG muropeptides released upon degradation may be delivered into the host cell cytoplasm by endogenous transporters whereby they would stimulate Nod-dependent epithelial inflammatory responses (17). (B) Listeria pgdA mutants are taken up into macrophage phagosomes, degraded by phagosomal lysozyme, and release lipoteichoic acid that is sensed by phagosomal TLR2 and PG murpeptides that can be transported out of the phagosome and detected in the cytosol by Nod proteins. Ligation of these PRRs induces an NF-κB-dependent inflammatory response by the macrophage. (C) Listeria pgdA mutants cannot escape macrophage phagosomes and therefore are unable to efficiently spread within systemic sites.
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