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. 2007 Apr;51(4):1556-8.
doi: 10.1128/AAC.00893-06. Epub 2007 Jan 12.

Combination of tigecycline and N-acetylcysteine reduces biofilm-embedded bacteria on vascular catheters

Saima Aslam  1 , Barbara W Trautner, Venkat Ramanathan, Rabih O Darouiche
Affiliations

Combination of tigecycline and N-acetylcysteine reduces biofilm-embedded bacteria on vascular catheters

Saima Aslam et al. Antimicrob Agents Chemother. 2007 Apr.

Abstract

To assess the efficacy of an antibiofilm/antimicrobial agent combination, we incubated catheter segments colonized with one of six studied bacterial organisms in N-acetylcysteine, tigecycline, N-acetylcysteine-tigecycline, or saline. Segments were washed, sonicated, and cultured. N-acetylcysteine-tigecycline significantly decreased all viable biofilm-associated bacteria and was synergistic for methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.

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Figures

FIG. 1.
FIG. 1.
The effect of normal saline control, NAC, tigecycline, and NAC-tigecycline combination on bacterial colony counts of different organisms. Each bar represents mean CFU per centimeter of catheter at different time points along with respective standard errors of the means. The y axis is on a logarithmic scale. The horizontal lines denote the lower limit of detection (LLD) of 10 CFU/cm. *, P < 0.05 compared to the control at the same time. §, P < 0.05 compared to the combination at the same time. (Microsoft Excel was used to create the graph.)
See this image and copyright information in PMC

References

    1. Curtin, J., M. Cormican, G. Fleming, J. Keelehan, and E. Colleran. 2003. Linezolid compared with eperezolid, vancomycin, and gentamicin in an in vitro model of antimicrobial lock therapy for Staphylococcus epidermidis central venous catheter-related biofilm infections. Antimicrob. Agents Chemother. 47:3145-3148. - PMC - PubMed
    1. Darouiche, R. O. 2001. Device-associated infections: a macroproblem that starts with microadherence. Clin. Infect. Dis. 33:1567-1572. - PubMed
    1. Darouiche, R. O., A. Dhir, A. J. Miller, G. C. Landon, I. I. Raad, and D. M. Musher. 1994. Vancomycin penetration into biofilm covering infected prostheses and effect on bacteria. J. Infect. Dis. 170:720-723. - PubMed
    1. Digiovine, B., C. Chenoweth, C. Watts, and M. Higgins. 1999. The attributable mortality and costs of primary nosocomial bloodstream infections in the intensive care unit. Am. J. Respir. Crit. Care Med. 160:976-981. - PubMed
    1. El-Azizi, M., S. Rao, T. Kanchanapoom, and N. Khardori. 2005. In vitro activity of vancomycin, quinupristin/dalfopristin, and linezolid against intact and disrupted biofilms of staphylococci. Ann. Clin. Microbiol. Antimicrob. 4:2. - PMC - PubMed

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