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. 2007 Apr;51(4):1504-7.
doi: 10.1128/AAC.01455-06. Epub 2007 Jan 12.

Activity of daptomycin alone and in combination with rifampin and gentamicin against Staphylococcus aureus assessed by time-kill methodology

Kim Credito  1 , Gengrong Lin, Peter C Appelbaum
Affiliations

Activity of daptomycin alone and in combination with rifampin and gentamicin against Staphylococcus aureus assessed by time-kill methodology

Kim Credito et al. Antimicrob Agents Chemother. 2007 Apr.

Abstract

The synergistic effects of daptomycin plus gentamicin or rifampin were tested against 50 Staphylococcus aureus strains, with daptomycin MICs ranging between 0.25 and 8 microg/ml. Daptomycin sub-MICs combined with gentamicin concentrations lower than the MIC yielded synergy in 34 (68%) of the 50 strains. Daptomycin combined with rifampin yielded synergy in one vancomycin-intermediate S. aureus strain only, and virtually all synergy occurred between daptomycin and gentamicin.

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Figures

FIG. 1.
FIG. 1.
(A) Daptomycin-gentamicin against a VISA strain; (B) daptomycin-gentamicin against a community-acquired MRSA strain.
See this image and copyright information in PMC

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