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Randomized Controlled Trial
. 2007 Jan;195(1):83-8.
doi: 10.1097/01.nmd.0000252313.49043.f2.

Impact of supported housing on clinical outcomes: analysis of a randomized trial using multiple imputation technique

An-Lin Cheng  1 , Haiqun Lin, Wesley Kasprow, Robert A Rosenheck
Affiliations
Randomized Controlled Trial

Impact of supported housing on clinical outcomes: analysis of a randomized trial using multiple imputation technique

An-Lin Cheng et al. J Nerv Ment Dis. 2007 Jan.

Abstract

In 1992, the US Department of Housing and Urban Development (HUD) and the US Department of Veterans Affairs (VA) established the HUD-VA Supported Housing (HUD-VASH) Program to provide integrated clinical and housing services to homeless veterans with psychiatric and/or substance abuse disorders at 19 sites. At four sites, 460 subjects were randomly assigned to one of the three groups: (1) HUD-VASH, with both Section 8 vouchers and intensive case management; (2) case management only; and (3) standard VA care. A previous publication found HUD-VASH resulted in superior housing outcomes but yielded no benefits on clinical outcomes. Since many participants missed prescheduled visits during the follow-up period and follow-up rates were quite different across the groups, we reanalyzed these data using multiple imputation statistical methods to account for the missing observations. Significant benefits were found for HUD-VASH in drug and alcohol abuse outcomes that had not previously been identified.

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Figures

FIGURE 1
FIGURE 1
Estimated days intoxicated over 3 years: repeated-measures analysis without multiple imputation. Days intoxicated for past 30 days at each visit time point (baseline = 0, 6, 12, 18, 24, 30, 36 months) were estimated and plotted against time point for three groups before multiple imputation. By inspecting this plot, we cannot see the significant different of days intoxicated among three groups since the lines are tangled together at some time points.
FIGURE 2
FIGURE 2
Days intoxicated over 3 years by treatment group: repeated-measures analysis following multiple imputation. After the multiple imputation for missing values, we plotted the estimated days intoxicated against the seven visiting time points. From this plot, we can tell that the HUD-VASH group has less days intoxicated compared with the other two groups, and this finding is supported statistically (p value= 0.018).
See this image and copyright information in PMC

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