Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991;13(7):1027-30.
doi: 10.1016/0192-0561(91)90057-e.

FK-506 prevents diabetes in diabetes-prone BB/Wor rats

F Nicoletti  1 , P L Meroni, W Barcellini, S Grasso, M O Borghi, M Lunetta, R Di Marco, S Stefani, L Mughini
Affiliations

FK-506 prevents diabetes in diabetes-prone BB/Wor rats

F Nicoletti et al. Int J Immunopharmacol. 1991.

Abstract

The effect of the immunosuppressant FK-506 on the development of diabetes in BB/Wor rats was investigated. Using a treatment schedule (25 micrograms i.m. from day 27 to 120), not associated with detectable general ill effects, this drug was found to completely inhibit the appearance hyperglycemia and to reduce the histological signs of pancreatic insulitis. The treatment was also able to reduce the percentages of Ia+ T-lymphocytes and to block the appearance of detectable serum levels of gamma interferon (IFN).

PubMed Disclaimer

LinkOut - more resources