doi: 10.1021/jo0616512.
One-pot asymmetric synthesis of either diastereomer of tert-butanesulfinyl-protected amines from ketones
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- PMID: 17221983
- DOI: 10.1021/jo0616512
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One-pot asymmetric synthesis of either diastereomer of tert-butanesulfinyl-protected amines from ketones
J Org Chem.
.
Abstract
A one-pot method for the asymmetric synthesis of tert-butanesulfinyl-protected amines is described. Condensation of aryl alkyl and dialkyl ketones with tert-butanesulfinamide followed by in situ reduction with the appropriate reagent provides either diastereomer of the sulfinamide products in good yields and with diastereomeric ratios of up to 99:1.
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