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Review
. 2007 Jan;11(1):3-5.
doi: 10.1016/j.ccr.2006.12.007.

Hit 'em where they live: targeting the cancer stem cell niche

Zeng-Jie Yang  1 , Robert J Wechsler-Reya
Affiliations
Free article
Review

Hit 'em where they live: targeting the cancer stem cell niche

Zeng-Jie Yang et al. Cancer Cell. 2007 Jan.
Free article

Abstract

Cancer stem cells (CSCs) are thought to be critical for initiation and propagation of many types of cancer. Because these cells are resistant to conventional therapies, they have been very difficult to eliminate. A study in this issue of Cancer Cell suggests that brain tumor CSCs live in a "vascular niche" that promotes their long-term growth and self-renewal. Disrupting this niche impairs CSC self-renewal and thereby significantly inhibits the growth of tumors. Targeting the unique microenvironment of CSCs may be the key to effective cancer therapy.

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  • A perivascular niche for brain tumor stem cells.
    Calabrese C, Poppleton H, Kocak M, Hogg TL, Fuller C, Hamner B, Oh EY, Gaber MW, Finklestein D, Allen M, Frank A, Bayazitov IT, Zakharenko SS, Gajjar A, Davidoff A, Gilbertson RJ. Calabrese C, et al. Cancer Cell. 2007 Jan;11(1):69-82. doi: 10.1016/j.ccr.2006.11.020. Cancer Cell. 2007. PMID: 17222791

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