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Review
. 2007 Feb;147(2):217-26.
doi: 10.1111/j.1365-2249.2006.03301.x.

Translational mini-review series on Toll-like receptors: recent advances in understanding the role of Toll-like receptors in anti-viral immunity

A G Bowie  1
Affiliations
Review

Translational mini-review series on Toll-like receptors: recent advances in understanding the role of Toll-like receptors in anti-viral immunity

A G Bowie. Clin Exp Immunol. 2007 Feb.

Abstract

(TLRs) respond to pathogens to initiate the innate immune response and direct adaptive immunity, and evidence to date suggests that they have a role in the detection of viruses. Many viral macromolecules have been shown to activate anti-viral signalling pathways via TLRs, leading to the induction of cytokines and interferons, while viruses also have means of not only evading detection by TLRs, but also of subverting these receptors for their own purposes. This review discusses the role of TLRs in the context of other known viral detection systems, and examines some of the often surprising results from studies using mice deficient in TLRs and their adaptors, in an attempt to unravel the particular contribution of TLRs to anti-viral immunity.

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References

    1. Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell. 2006;124:783–801. - PubMed
    1. Zambon RA, Nandakumar M, Vakharia VN, Wu LP. The Toll pathway is important for an anti-viral response in Drosophila. Proc Natl Acad Sci. 2005;102:7257–62. - PMC - PubMed
    1. Balachandran S, Roberts PC, Brown LE, et al. Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection. Immunity. 2000;13:129–41. - PubMed
    1. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-[kappa]B by Toll-like receptor 3. Nature. 2001;413:732–8. - PubMed
    1. Schroder M, Bowie AG. TLR3 in anti-viral immunity: key player or bystander? Trends Immunol. 2005;26:462–8. - PubMed

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