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Review
. 2006 Fall;6(4):221-6.

The prevention of gastropathy and upper abdominal symptoms caused by nonsteroidal anti-inflammatory drugs

Nimish Vakil  1
Affiliations
  • PMID: 17224894
Review

The prevention of gastropathy and upper abdominal symptoms caused by nonsteroidal anti-inflammatory drugs

Nimish Vakil. Rev Gastroenterol Disord. 2006 Fall.

Abstract

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is increasing, primarily due to arthritis in the aging population. This article reviews current data on the risk of gastrointestinal complications related to NSAIDs and strategies to manage risk in patients taking these agents. Risks of NSAID use include gastrointestinal ulceration, hemorrhage, or perforation; renal dysfunction; death; and dyspepsia. Alternate therapies include use of non-NSAID analgesics; low-dose NSAIDs; and concurrent administration of cytoprotective agents with NSAIDs, acid inhibitors, proton pump inhibitors, and COX-2 agents.

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