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. 2007 Apr;14(4):1424-30.
doi: 10.1245/s10434-006-9302-7. Epub 2007 Jan 17.

Non-radical diagnostic biopsies do not negatively influence melanoma patient survival

Barbara G Molenkamp  1 , Berbel J R Sluijter, Benny Oosterhof, Sybren Meijer, Paul A M van Leeuwen
Affiliations

Non-radical diagnostic biopsies do not negatively influence melanoma patient survival

Barbara G Molenkamp et al. Ann Surg Oncol. 2007 Apr.

Abstract

Background: In fair-skinned Caucasian populations both the incidence and mortality rates of cutaneous melanoma have been increasing over the past decades. With adjuvant therapies still being under investigation, early detection is the only way to improve melanoma patient survival. The influence of incisional biopsies on melanoma patient survival has been discussed for many years. This study investigates both the influence of diagnostic biopsy type and the presence of residual tumor cells in the re-excision specimen on disease free and overall survival.

Methods: After (partial) removal of a pigmented skin lesion 471 patients were diagnosed with stage I/II melanoma and underwent re-excision and a sentinel node biopsy. All patients were followed prospectively, mean follow up >5 years. Patients were divided according to their diagnostic biopsy type (wide excision biopsy, narrow excision biopsy, excision biopsy with positive margins and incisional biopsy) and the presence of residual tumor cells in their re-excision specimen. Survival analysis was done using Cox's proportional hazard model adjusted for eight important confounders of melanoma patient survival.

Results: The diagnostic biopsy was wide in 279 patients, narrow in 109 patients, 52 patients underwent an excision biopsy with positive margins and 31 patients an incisional biopsy. In 41 patients residual tumor cells were present in the re-excision specimen. Both the diagnostic biopsy type and the presence of tumor cells in the re-excision specimen did not influence disease free and overall survival of melanoma patients.

Conclusions: Non-radical diagnostic biopsies do not negatively influence melanoma patient survival.

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Figures

FIG. 1.
FIG. 1.
A Disease free survival rates and B overall survival rates according to the initial biopsy type.
FIG. 2.
FIG. 2.
A Disease free survival rates and B overall survival rates according to the presence of residual tumor cells in the re-excision specimen.
See this image and copyright information in PMC

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References

    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1016/j.ejca.2004.06.003', 'is_inner': False, 'url': 'https://doi.org/10.1016/j.ejca.2004.06.003'}, {'type': 'PubMed', 'value': '15519506', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/15519506/'}]}
    2. de Vries E, Coebergh JW. Cutaneous malignant melanoma in Europe. Eur J Cancer 2004; 40:2355–66 - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1111/j.1365-2133.2005.06386.x', 'is_inner': False, 'url': 'https://doi.org/10.1111/j.1365-2133.2005.06386.x'}, {'type': 'PubMed', 'value': '15787817', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/15787817/'}]}
    2. de Vries E, van de Poll-Franse LV, Louwman WJ, de Gruijl FR, Coebergh JW. Predictions of skin cancer incidence in the Netherlands up to 2015. Br J Dermatol 2005; 152:481–8 - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '14709122', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/14709122/'}]}
    2. English DR, Del Mar C, Burton RC. Factors influencing the number needed to excise: excision rates of pigmented lesions by general practitioners. Med J Aust 2004; 180:16–9 - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1016/S0140-6736(02)09779-9', 'is_inner': False, 'url': 'https://doi.org/10.1016/s0140-6736(02)09779-9'}, {'type': 'PubMed', 'value': '12241928', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/12241928/'}]}
    2. MacKie RM, Bray CA, Hole DJ, et al. Incidence of and survival from malignant melanoma in Scotland: an epidemiological study. Lancet 2002; 360:587–91 - PubMed
    1. Nederlandse Melanoom werkgroep. Richtlijn Melanoom van de huid, versie: 1.1. Alphen aan de Rijn: Van Zuiden Communications B.V., 2005