doi: 10.1128/aem.57.8.2420-2425.1991.
Distribution, clearance, and mortality of environmental pseudomonads in mice upon intranasal exposure
Affiliations
- PMID: 1722663
- PMCID: PMC183589
- DOI: 10.1128/aem.57.8.2420-2425.1991
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Distribution, clearance, and mortality of environmental pseudomonads in mice upon intranasal exposure
Appl Environ Microbiol.
1991 Aug.
Abstract
When introduced intranasally, P. cepacia AC1100 (approximately 10(8) CFU/animal) and P. aeruginosa AC869 (approximately 10(3) CFU/animal) were readily cleared from the mouse. However, a approximately 10(7)-CFU dose of AC869 persisted for 14 days. Strain AC869 had a 50% lethal dose of 2.7 x 10(7) CFU. Slight morbidity occurred in animals treated with approximately 10(7) CFU of AC869 or approximately 10(8) CFU of AC1100.
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