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. 1991 Aug;57(8):2420-5.
doi: 10.1128/aem.57.8.2420-2425.1991.

Distribution, clearance, and mortality of environmental pseudomonads in mice upon intranasal exposure

S E George  1 , M J Kohan, D A Whitehouse, J P Creason, C Y Kawanishi, R L Sherwood, L D Claxton
Affiliations

Distribution, clearance, and mortality of environmental pseudomonads in mice upon intranasal exposure

S E George et al. Appl Environ Microbiol. 1991 Aug.

Abstract

When introduced intranasally, P. cepacia AC1100 (approximately 10(8) CFU/animal) and P. aeruginosa AC869 (approximately 10(3) CFU/animal) were readily cleared from the mouse. However, a approximately 10(7)-CFU dose of AC869 persisted for 14 days. Strain AC869 had a 50% lethal dose of 2.7 x 10(7) CFU. Slight morbidity occurred in animals treated with approximately 10(7) CFU of AC869 or approximately 10(8) CFU of AC1100.

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