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. 2007 Apr;88 Suppl 1(Suppl 1):S71-84.
doi: 10.1016/j.drugalcdep.2006.12.012. Epub 2007 Jan 16.

Personality disorders in early adolescence and the development of later substance use disorders in the general population

Patricia Cohen  1 , Henian Chen, Thomas N Crawford, Judith S Brook, Kathy Gordon
Affiliations

Personality disorders in early adolescence and the development of later substance use disorders in the general population

Patricia Cohen et al. Drug Alcohol Depend. 2007 Apr.

Abstract

Assessments of personality disorder (PD) and conduct disorder (CD) in a random community sample at mean age 13 were employed to predict subsequent substance abuse disorder (SUD), trajectories of symptoms of abuse or dependence on alcohol, marijuana, or other illicit substances, and hazard of initiating marijuana use over the subsequent decade. Personality disorders and conduct disorder were associated with diagnoses and symptoms of SUDs in every model and their effects were independent of correlated family risks, participant sex, and other Axis I disorders. Specific elevated PD symptoms in early adolescence were also associated with differential trajectories of already initiated SUD symptoms as well as elevated risk for future onset of SUD symptoms. For several models the greatest of these effects were shown for borderline PD and for conduct disorder, the predecessor of adult antisocial PD. Passive-aggressive PD also showed independent elevation effects on substance use symptoms for alcohol and marijuana. Analyses over 30 years suggest that Cluster B PD (borderline, histrionic, narcissistic) are independent risks for development of SUD and warrant clinical attention.

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Figures

Figure 1
Figure 1
Trajectories of alcohol abuse and dependency symptoms by adolescent PD diagnosis
Figure 2
Figure 2
Trajectories of marijuana abuse and dependency symptoms by adolescent PD diagnosis
Figure 3
Figure 3
Trajectories of illicit drug abuse and dependency symptoms by adolescent PD diagnosis
Figure 4
Figure 4
Early alcohol problems and paranoid PD and subsequent trajectory of alcohol symptoms
Figure 5
Figure 5
Early marijuana problem and schizotypal PD and subsequent trajectory of marijuana symptoms
See this image and copyright information in PMC

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