What does the brain do when you fake it? An FMRI study of pantomimed and real grasping

Abstract

Given that studying neural bases of actions is very challenging with fMRI, numerous experiments have used pantomimed actions as a proxy to studying neural circuits of real actions. However, the underlying assumption that the same neural mechanisms mediate real and pantomimed actions has never been directly tested. Moreover, the assumption is called into question by neuropsychological evidence suggesting that real actions depend on the dorsal stream of visual processing whereas pretend actions also recruit the ventral stream. Here, we directly tested these ideas in neurologically intact subjects. Ten right-handed participants performed four tasks: 1) grasping real three-dimensional objects, 2) reaching toward the objects and touching them with the knuckle without hand preshaping, 3) pantomimed grasping in an adjacent location where no object was present, and 4) pantomimed reaching toward an adjacent location. As expected, in the anterior intraparietal area, there was significantly higher activation during real grasping than that during real reaching. However, the activation difference between pantomimed grasping and pantomimed reaching did not reach statistical significance. There was also no effect of pantomimed grasping within the ventral stream, including an object-selective area in the lateral occipital cortex. Instead, we found that pantomimed grasping was mediated by right-hemisphere activation, particularly the right parietal cortex. These results suggest that areas typically invoked by real actions may not necessarily be driven by "fake" actions. Moreover, pantomimed grasping may not tap object-related areas within the ventral stream, but rather may rely on mechanisms within the right hemisphere that are recruited by artificial and less practiced actions.