The pathogenesis of MALT lymphomas: where do we stand?
- PMID: 17230229
- DOI: 10.1038/sj.leu.2404517
The pathogenesis of MALT lymphomas: where do we stand?
Abstract
Mucosa-associated lymphoid tissue (MALT) lymphoma is a heterogeneous form of a B-cell non-Hodgkin's lymphoma with extranodal location. The gastrointestinal tract is the most common site of disease, but involvement of multiple other organ systems has been documented. Four translocations, t(11;18)(q21;q21), t(1;14)(p22;q32), t(14;18)(q32;q21) and t(3;14)(p13;q32), are specifically associated with MALT lymphoma. Remarkably, the genes targeted by at least three of these translocations are involved in one and the same pathway, leading to the activation of nuclear factor-kappaB (NF-kappaB). This review presents MALT lymphoma as a model of how sustained inflammation increases the risk of genotoxic insults and how these genetic events initiate oncogenesis.
Similar articles
-
MALT lymphoma with t(14;18)(q32;q21)/IGH-MALT1 is characterized by strong cytoplasmic MALT1 and BCL10 expression.J Pathol. 2005 Feb;205(3):293-301. doi: 10.1002/path.1715. J Pathol. 2005. PMID: 15682443
-
Molecular pathogenesis of mucosa-associated lymphoid tissue lymphoma.J Clin Oncol. 2005 Sep 10;23(26):6370-8. doi: 10.1200/JCO.2005.05.011. J Clin Oncol. 2005. PMID: 16155022 Review.
-
Primary cutaneous marginal zone B-cell lymphoma may exhibit both the t(14;18)(q32;q21) IGH/BCL2 and the t(14;18)(q32;q21) IGH/MALT1 translocation: an indicator for clonal transformation towards higher-grade B-cell lymphoma?Am J Dermatopathol. 2007 Jun;29(3):231-6. doi: 10.1097/DAD.0b013e31804795a6. Am J Dermatopathol. 2007. PMID: 17519619
-
Chromosomal translocation t(11;18)(q21;q21) in gastrointestinal mucosa associated lymphoid tissue lymphoma.J Clin Pathol. 2003 Jan;56(1):36-42. doi: 10.1136/jcp.56.1.36. J Clin Pathol. 2003. PMID: 12499431 Free PMC article. Review.
-
Translocations t(11;18)(q21;q21) and t(14;18)(q32;q21) are the main chromosomal abnormalities involving MLT/MALT1 in MALT lymphomas.Leukemia. 2003 Nov;17(11):2225-9. doi: 10.1038/sj.leu.2403122. Leukemia. 2003. PMID: 12931213
Cited by
-
Clinicopathological Analysis of Ocular Adnexal Extranodal Marginal Zone B-Cell Lymphoma with IgG4-Positive Cells.PLoS One. 2015 Jun 25;10(6):e0131458. doi: 10.1371/journal.pone.0131458. eCollection 2015. PLoS One. 2015. PMID: 26111022 Free PMC article.
-
Emu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappaB pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma.Blood. 2009 Nov 5;114(19):4158-68. doi: 10.1182/blood-2008-12-192583. Epub 2009 Aug 20. Blood. 2009. PMID: 19696203 Free PMC article.
-
MIF coordinates the cell cycle with DNA damage checkpoints. Lessons from knockout mouse models.Cell Div. 2007 Jul 19;2:22. doi: 10.1186/1747-1028-2-22. Cell Div. 2007. PMID: 17640378 Free PMC article.
-
Management of Extranodal Marginal Zone Lymphoma: Present and Upcoming Perspectives.Cancers (Basel). 2022 Jun 19;14(12):3019. doi: 10.3390/cancers14123019. Cancers (Basel). 2022. PMID: 35740684 Free PMC article. Review.
-
Primary Gastric Lymphoma, Epidemiology, Clinical Diagnosis, and Treatment.Cancer Control. 2018 Jan-Mar;25(1):1073274818778256. doi: 10.1177/1073274818778256. Cancer Control. 2018. PMID: 29779412 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
