[The filamin in cell signaling]

Abstract

This review describes structure and functions of the group of actin-binding proteins--the filamins. Up-to-date facts demonstrate that filamis take part in different regulatory processes in the cell. The filamins have diverse functions--organization of actin polymers into orthogonal networks (three-dimensional scaffolding), attachment of actin filaments to transmembrane receptors, regulation of actin-myosin interaction, regulation of actin assembly. In addition to its main role of the cytoskeleton structural protein, filamin can serve as scaffold protein for formation of signal proteins complexes. One interacts with transcription factors and takes part in signal transduction from cytoplasmic membranes to the nucleus. C-terminal end of filamin interacts with androgen receptor and through cleavage by calpain translocates to the nucleus. Analysis of reviewed experimental dates suggests the conception that intracellular signalization mediated by cytoskeleton proteins is connected with reorganization of the cytoskeleton.