Review
doi: 10.1111/j.1365-2567.2006.02501.x.
On a key postulate of T-cell receptor restrictive function: the V-gene loci act as a single pool encoding recognition of the polymorphic alleles of the species major histocompatibility complex
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- PMID: 17233741
- PMCID: PMC2265876
- DOI: 10.1111/j.1365-2567.2006.02501.x
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Review
On a key postulate of T-cell receptor restrictive function: the V-gene loci act as a single pool encoding recognition of the polymorphic alleles of the species major histocompatibility complex
Immunology.
2007 Jan.
Abstract
The proposition that single Valpha or Vbeta gene segments specify the recognition of the allele-specific determinants expressed on the major histocompatibility complex-encoded restricting elements of the species has as its consequence a totally different picture of the functioning of the T-cell receptor. This commentary justifies this assumption and outlines some of its most important consequences.
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References
-
- Zinkernagel RM, Doherty PC. Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis. Nature. 1974;251:547–8. - PubMed
-
- Matzinger P, Bevan MJ. Hypothesis. Why do so many lymphocytes respond to major histocompatibility antigens? Cellular Immunol. 1977;29:1–5. - PubMed
-
- Cohn M, Epstein R. T-cell inhibition of humoral responsiveness. II. Theory on the role of restrictive recognition in immune regulation. Cellular Immunol. 1978;39:125–53. - PubMed
-
- Langman RE. Cell-mediated immunity and the major histocompatability complex. Rev Physiol Biochem Pharmacol. 1978;81:1–37. - PubMed
-
- Cohn M. The T-cell receptor mediating restrictive recognition of antigen. Cell. 1983;33:657–69. - PubMed
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