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. 2006 Feb;6(31):18-23.

Defeating drug resistance in cancer

Michael M Gottesman  1 , Joseph Ludwig, Di Xia, Gergely Szakács
Affiliations
  • PMID: 17234123
Free article

Defeating drug resistance in cancer

Michael M Gottesman et al. Discov Med. 2006 Feb.
Free article

Abstract

Multiple resistance to cytotoxic cancer drugs dramatically reduces the effectiveness of these drugs on many occasions. ABC (ATP-binding cassette) transporters pump out cytotoxic cancer drugs from cells, preventing them from reaching therapeutic levels. However, co-administration ABC transporter inhibitors with cytotoxic cancer drugs did not effectively improve the treatment outcome. The mechanisms and remedies are discussed.

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