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. 1991 Sep 6;558(2):315-20.
doi: 10.1016/0006-8993(91)90784-s.

Basic fibroblast growth factor promotes in vivo cerebral angiogenesis in chronic forebrain ischemia

M K Lyons  1 , R E Anderson, F B Meyer
Affiliations

Basic fibroblast growth factor promotes in vivo cerebral angiogenesis in chronic forebrain ischemia

M K Lyons et al. Brain Res. .

Abstract

This experiment was designed to determine if intraventricular administration of basic fibroblast growth factor (bFGF) could promote cerebral angiogenesis in a model of mild chronic forebrain ischemia. Wistar rats underwent bilateral carotid artery ligation. Animals received intraventricular injections of bFGF every 4 days for 28 days. Basic fibroblast growth factor caused a significant dose-dependent increase in capillary density compared to ischemic controls in all regions examined. These results support the hypothesis that chronic intraventricular administration of bFGF induces in vivo cerebral angiogenesis.

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