Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006;2(2):81-6.
doi: 10.1007/s12015-006-0013-z.

Double cord blood transplants: filling a niche?

Affiliations
Review

Double cord blood transplants: filling a niche?

Richard L Haspel et al. Stem Cell Rev. 2006.

Abstract

Over the last decade, umbilical cord blood (CB) has become a viable option for hematopoietic stem cell transplants. A limiting factor has been the 10-fold lower cell dose in a CB unit compared with harvested bone marrow or peripheral blood stem cells. The low cell dose leads to delayed engraftment and an increase in graft failure. Double cord blood transplants represent a novel strategy to overcome this limitation. This review will cover the rationale behind and clinical results of double cord blood transplant studies. The chimerism data from these studies reveal that typically only one CB "wins the battle" for engraftment. These results may have important scientific implications in terms of understanding the nature of the hematopoietic stem cell niche and how modulation of this niche may impact transplant outcomes.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Blood. 2001 Apr 15;97(8):2293-9 - PubMed
    1. Blood. 2004 May 1;103(9):3313-9 - PubMed
    1. Blood. 2003 Aug 1;102(3):1108-13 - PubMed
    1. N Engl J Med. 2004 Nov 25;351(22):2276-85 - PubMed
    1. Blood. 2006 May 1;107(9):3804-7 - PubMed

Substances

LinkOut - more resources