Review
doi: 10.1016/0167-5699(91)90016-m.
Maintenance of immunological memory: a role for CD5+ B cells?
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- PMID: 1723877
- DOI: 10.1016/0167-5699(91)90016-m
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Review
Maintenance of immunological memory: a role for CD5+ B cells?
Immunol Today.
1991 Dec.
Abstract
How memory is retained is an immunological mystery. One possibility, argued here by Fons UytdeHaag and colleagues, is that memory is imprinted in the somatically-mutated Ig expressed by certain CD5+ B cells. The theory proposes that the Ig expressed by this self-renewing population acts as surrogate antigen, selecting and stimulating emerging antigen-specific lymphocytes.
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