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Review
. 1991 Dec;12(12):439-42.
doi: 10.1016/0167-5699(91)90016-m.

Maintenance of immunological memory: a role for CD5+ B cells?

F UytdeHaag  1 , R van der Heijden, A Osterhaus
Affiliations
Review

Maintenance of immunological memory: a role for CD5+ B cells?

F UytdeHaag et al. Immunol Today. 1991 Dec.

Abstract

How memory is retained is an immunological mystery. One possibility, argued here by Fons UytdeHaag and colleagues, is that memory is imprinted in the somatically-mutated Ig expressed by certain CD5+ B cells. The theory proposes that the Ig expressed by this self-renewing population acts as surrogate antigen, selecting and stimulating emerging antigen-specific lymphocytes.

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