Case-control study of risk factors for the development of post-transplant lymphoproliferative disease in a pediatric heart transplant cohort
- PMID: 17239124
- DOI: 10.1111/j.1399-3046.2006.00609.x
Case-control study of risk factors for the development of post-transplant lymphoproliferative disease in a pediatric heart transplant cohort
Abstract
PTLD is an important complication following heart transplantation. To better define the risk factors of PTLD in children, we performed a case-control study. All pediatric cardiac transplant recipients who developed their first episode of PTLD were matched by age (+/-1 yr) and time since transplant (+/-1 yr) with those who did not. PTLD occurred in nine of 95 cardiac transplant recipients (9%), 0.3-7.8 yr following cardiac transplantation (median = 2.5 yr). Patients were 0.1-16.4 yr (median = 3.7) at transplantation. Biopsies revealed polymorphic B cell hyperplasia (three), polymorphic B cell lymphoma (one), monomorphic diffuse large cell B cell lymphoma (three) and monomorphic Burkitt's-like lymphoma (two). Patients who developed PTLD were at no greater risk of death (p = 0.31). Recipient EBV seronegativity at time of transplant (p = 0.08), EBV seroconversion (p = 0.013) and recipient CMV seronegativity (p = 0.015) were associated with the development of PTLD by conditional logistic regression; sex, race, donor age, recipient diagnosis, donor CMV seropositivity, recipient treatment for CMV infection, EBV seropositivity at the time of PTLD diagnosis, and number of rejection episodes, treated rejection episodes, and lympholytics used were not. There was no significant association between PTLD and death in our recipients. EBV seroconversion and recipient CMV seronegativity were associated with the development of PTLD.
Similar articles
-
Diagnosis and treatment of post-transplantation lymphoproliferative disorder in pediatric heart transplant patients.Pediatr Transplant. 2009 Feb;13(1):54-62. doi: 10.1111/j.1399-3046.2008.00969.x. Epub 2008 Jun 1. Pediatr Transplant. 2009. PMID: 18518912
-
Post-transplant lymphoproliferative disorder following pediatric heart transplantation.Pediatr Transplant. 2006 Feb;10(1):60-6. doi: 10.1111/j.1399-3046.2005.00401.x. Pediatr Transplant. 2006. PMID: 16499589
-
Posttransplant lymphoproliferative disorders in transplant recipients.Transplant Proc. 2006 Mar;38(2):641-5. doi: 10.1016/j.transproceed.2005.12.093. Transplant Proc. 2006. PMID: 16549195
-
[Diffuse lymphoproliferative disease after renal transplantation and its relation with Epstein-Barr virus. Experience at one center].Nefrologia. 2002;22(5):463-9. Nefrologia. 2002. PMID: 12497748 Review. Spanish.
-
Post-transplant lymphoproliferative disorders: molecular basis of disease histogenesis and pathogenesis.Hematol Oncol. 2005 Jun;23(2):61-7. doi: 10.1002/hon.751. Hematol Oncol. 2005. PMID: 16216037 Review.
Cited by
-
Therapeutic options in post-transplant lymphoproliferative disorders.Ther Adv Hematol. 2011 Dec;2(6):393-407. doi: 10.1177/2040620711412417. Ther Adv Hematol. 2011. PMID: 23556105 Free PMC article.
-
A Review of Induction with Rabbit Antithymocyte Globulin in Pediatric Heart Transplant Recipients.Ann Transplant. 2018 May 15;23:322-333. doi: 10.12659/AOT.908243. Ann Transplant. 2018. PMID: 29760372 Free PMC article. Review.
-
Late-Onset Posttransplant Lymphoproliferative Disorder Results in Jejunal Stricture Managed with Endoscopic Dilation.Case Rep Gastrointest Med. 2021 Aug 3;2021:5583665. doi: 10.1155/2021/5583665. eCollection 2021. Case Rep Gastrointest Med. 2021. PMID: 34394999 Free PMC article.
-
Persistent Epstein-Barr viral load in Epstein-Barr viral naïve pediatric heart transplant recipients: Risk of late-onset post-transplant lymphoproliferative disease.World J Transplant. 2016 Dec 24;6(4):729-735. doi: 10.5500/wjt.v6.i4.729. World J Transplant. 2016. PMID: 28058224 Free PMC article.
-
Pediatric post-transplant diffuse large B cell lymphoma after cardiac transplantation.Int J Hematol. 2009 Mar;89(2):209-213. doi: 10.1007/s12185-008-0250-9. Epub 2009 Jan 21. Int J Hematol. 2009. PMID: 19156500
MeSH terms
LinkOut - more resources
Full Text Sources
Medical