doi: 10.1016/j.bmcl.2006.12.085.
Epub 2007 Jan 4.
Antiviral activity of berberine and related compounds against human cytomegalovirus
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- PMID: 17239594
- DOI: 10.1016/j.bmcl.2006.12.085
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Antiviral activity of berberine and related compounds against human cytomegalovirus
Bioorg Med Chem Lett.
.
Abstract
Berberine chloride (1) and the structurally related compounds were assessed for the anti-human cytomegalovirus (HCMV) activity using the plaque assay. The anti-HCMV activity (IC(50) 0.68 microM) of 1 was equivalent to that (IC(50) 0.91 microM) of ganciclovir (GCV). The mechanism of action by which 1 inhibits the replication of HCMV is presumed to be different from that of GCV; 1 would interfere with intracellular events after virus penetration into the host cells and before viral DNA synthesis.
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